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Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

GLP-1RAs such as semaglutide are known to cross the bloodbrain barrier, suggesting that their pain-relieving effects could be mediated through brain structures such as the hypothalamus and brainstem, areas that regulate nociception [102]

Modulation of taste responsiveness and food preference by obesity and weight loss

Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R), a member of the GPCR family, is involved in the so-called GLP-1-based therapies for the treatment of type 2 diabetes mellitus

In terms of metabolic regulation, GLP-1RAs exert their effects through various pathways, including increasing insulin sensitivity, maintaining glucose homeostasis, promoting weight control, and improving lipid metabolism

Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents