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To view or add a comment, sign in While GLP-1 drugs offer substantial healthcare benefits, they can also have adverse effects

Cardiovascular disease (CVD) is the leading cause of death and disability in patients with type 2 diabetes

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Why Retatrutide May Show More Reward Blunting in Some Research Subjects The most plausible explanation lies in signal stacking : GLP-1 reduces hedonic and reward-driven feeding GIP modulates metabolic and central signaling Glucagon increases energy expenditure and output-oriented physiology Together, these signals may: Further suppress reward-seeking behaviors Reduce the relative salience of pleasure-based stimuli Shift behavioral and metabolic priorities toward efficiency and fuel utilization In some nervous systems, this tradeoff may be observed as reduced reward responsiveness or anhedonia-like features

A consistent weight loss of 1.52 lbs per week indicates your dose is effective
