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It differentially induces internalization of GIPR versus GLP-1R, with full internalization of GIPR but limited internalization of GLP-1R
Hydration: Keep fluids up, particularly while titrating, when GI effects peak
Tirzepatide works as a dual GIP and GLP-1 receptor agonist, meaning it activates two separate incretin pathways simultaneously
Excess sodium can also raise blood pressure and contribute to bloating or water retention
Take the medicines with you, unused, outside the EU within 90 days after purchase
