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Discussion Key Study Findings The findings from the NMA support the clinical effectiveness and safety of tirzepatide compared with semaglutide and liraglutide, for multiple clinical outcomes considered in the management of obesity and overweight in patients without T2D, including weight reduction and cardiometabolic risk factors, such as waist circumference, lipids, blood pressure and glycaemic parameters

It is more likely that increased HR results from a direct GLP-1 receptor-mediated effect on the endogenous sinoatrial pacemaker node of the heart, as GLP-1 receptors are expressed in the human heart in myocytes in the sinoatrial node [33]

Stopping without a plan is the biggest reason patients call GLP-1s a failure, especially for those already managing the overlap of PTSD and weight gain

The ongoing phase 3 studies in China are expected to run through 2024 and 2025, providing further insights into its long-term benefits and safety

Eficacia para el control del peso Los estudios han demostrado que la semaglutida puede provocar una prdida de peso significativa