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The extended absorption phase contributes to the sustained therapeutic effect throughout the dosing interval

Incretin-based therapies were not associated with an increased or decreased incidence of depression or self-harm compared with sulfonylureas

in adipose, adipocyte size and mitochondrial markers

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However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)