soul trial semaglutide trial: Semaglutida oral em pacientes diabéticos com doença aterosclerótica e/ou DRC SOUL trial: Oral semaglutide demonstrates
Description
Switching from semaglutide to tirzepatide is not a simple milligram-for-milligram swap

Impaired sensitivity to thyroid hormones is associated with hyperuricemia, obesity, and cardiovascular disease risk in subjects with subclinical hypothyroidism
Who should not take tirzepatide or semaglutide

The key distinctions become apparent when examining both mechanism and results

Mounjaro is a brand name

In July 2025 , the company lowered its full-year guidance, cutting expected midpoint sales growth to 11% and operating profit growth to 13% , down from 17% and 20% previously, roughly a 35% reduction in full-year expectations
