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The hunger-reducing mechanisms of GLP-1 drugs, as well as their side effects, may contribute to dehydration.

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Methods We selected individuals aged 45 years and older already treated with metformin living in Lombardy, Italy, and then split them into two groups if they initiated GLP-1 RAs or other antidiabetic drugs, between 2019 and 2021

Heres my protocol, taking it easy on the dose, since DAC peptides are long acting: Week 1 1.2 mg CJC-1295 DAC Week 2 2.4 mg (or switch to no-DAC + Ipamorelin if side effects demand it) Weeks 3 and 4 2.4 mg CJC-1295 weekly + 0.25 mg tirzepatide, twice weekly Measuring everything: Weekly blood: IGF-1, GH, GHRH, fasting glucose, insulin, HOMA-IR, ApoA1, ApoB, prolactin, cortisol Continuous CGM across all 4 weeks Continuous core body temp (eCelsius capsule), weekly Sleep, HR, HRV: 24/7 I'll post results as they arrive

Late Food Network star Anne Burrell had a bunch of pills nearby when her husband found her unresponsive on their shower floor

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