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The safety of GLP1 agonists for weight loss in patients with a history of breast cancer remains undefined as this group was excluded from the large, randomized trials leading to FDA approval of tirzepatide and semaglutide

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Numerous obesity-associated antitumor immunity defects have been implicated in impairment of antitumor immunity by obesity, including diminished tumor-associated macrophage (TAM) antigen presentation [20], altered TAM metabolism [21], and dysfunctional T cell metabolism [22, 23]

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