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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Azzam A.Y., et al

Rotate your injection site each week to prevent lipodystrophy (localized changes in fat tissue from repeated injections in the same spot)

The question is not "how do I prevent tirzepatide from wearing off?" The question is "how do I manage the first four weeks while steady state builds ?" Those are very different questions with very different answers

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Semaglutide activates only GLP-1 receptors while Tirzepatide activates both GIP and GLP-1 receptors simultaneously
