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doi: 10.1016/j.ejphar.2008.12.056

264,265 This could create an environment where beneficial bacterial strains can flourish, potentially enhancing metabolic health

This shift often leads to: Increased fat storage, particularly around the abdomen Slower metabolism Mood swings, poor sleep, and low energyall of which can make lifestyle changes more difficult By restoring hormonal balance, HRT can improve overall well-being and make weight loss more achievable

Y.et al (2016)

In terms of tolerability, tirzepatide generally causes fewer gastrointestinal side effects, making it a better option for those sensitive to nausea, while Semaglutide GLP-1 may cause mild to moderate gastrointestinal issues like nausea and diarrhea, which usually subside over time