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Future clinical studies should determine which patient groups should be targeted as potential candidates for the symptomatic and/or neuroprotective effects of GLP-1RAs, to find out, whether combinations of GLP-1RA with other classes of drugs can further enhance their effectiveness, and evaluate their long-term effect on the course of the disease and side effects

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Dulaglutide, like other GLP-1RAs, leads to weight loss or reduced gain alone or with non-insulin secretagogues [278]

We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes