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15 The subsequent transient decrease in venous return and cardiac output results in reduced blood pressure

After 12 weeks: By about three months, participants in the STEP 1 trial showed meaningful weight loss, with averages generally in the mid-single-digit percentage range, compared with minimal changes in the placebo group

Since a 10mg/ml vial contains 100 doses at the lowest dose (.10 mg) and 25 at the next lowest dose (.25 mg), it has far more of the drug than you could use in a month (1 dose a week)

One way that this reduction might occur is through desensitization, disassociation, or cointernalization of the dimer