dual agonist glp 1 Understand GLP-1/GIP Tirzepatide and Its Effect on Current Weight Loss Therapy Tirzepatide, a dual GIP/GLP-1 receptor

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Obesity and Type 2 diabetes represent global health challenges, and there is an unmet need for long-lasting and effective pharmacotherapies

Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials

We also present practical implications of these glucose-lowering agents for reducing the risk of adverse cardiovascular events and progressive renal comorbidity in patients with T2D and CVD.

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Recent advancementsincluding the approval of oral semaglutide (Rybelsus)have demonstrated the potential for effective oral peptide delivery, though such formulations still face significant pharmacokinetic and formulation-related challenges