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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Terasaki M, Nagashima M, Nohtomi K, Kohashi K, Tomoyasu M, Sinmura K, et al

Serious safety concerns are rare but include: Systemic infections : Immunocompromised individuals, those with central venous catheters, or patients with damaged gut barriers face increased risk of bacteremia or fungemia from probiotic organisms [19] [20] Antibiotic resistance transfer : Some probiotic strains may carry antibiotic resistance genes Metabolic complications : Rare cases of D-lactic acidosis have been reported with high-dose probiotic use [25] Specific populations requiring caution include patients with severe acute pancreatitis (based on the PROPATRIA trial showing increased mortality), short bowel syndrome, immunosuppression (HIV/AIDS, chemotherapy, organ transplant recipients), and critically ill individuals

It is injected subcutaneously in the abdomen, thigh, or upper arm

( A ) Uniform manifold approximation and projection (UMAP) plot showing clustering of intestinal epithelial cell types isolated from the crypts of WT mice and analyzed by single-cell RNA sequencing

Watson typically starts patients on liraglutide, which tends to be the gentlest and least expensive of the GLP-1s

Unlike some medications that peak and fade within hours, GLP-1 drugs have a long half-life. A half-life is the time it takes for the concentration of a drug in your body to reduce by half