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The FDA has granted accelerated approval of Wegovy (semaglutide) for adults with moderate to advanced metabolic dysfunction-associated steatohepatitis (MASH)

Unlike the well-known roles of GLP-1 and #PYY, the role of INSL5 is poorly understood, but this new research suggests it promotes colonic motility and in fact may be behind the cases of severe diarrhea (bile acid malabsorption in #IBS)

How this indication expansion will impact the ability for generic manufacturing of sema I am unsure, but my assumption is that generic sem and GLP-1s will be available long before resmetirom