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Rhamnocitrin decreases fibrosis of ovarian granulosa cells by regulating the activation of the PPAR/NF-B/TGF-1/Smad2/3 signaling pathway mediated by Wisp2

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In the two-year STEP 5 study, 77.1% of participants lost at least 5% of their body weight , and 36.1% achieved a reduction of 20% or more

10 or 15 mg once weekly) vs Reduce to tirzepatide 5 mg once weekly vs Placebo for 52 weeks (randomized 3:3:2 at week 60) Primary outcome: Percent change in bodyweight from baseline to week 112 Results: Primary outcome (percent change in bodyweight at week 112): Tirzepatide MTD -21.9%, Tirzepatide 5 mg -16.6%, Placebo -9.9% (estimated treatment difference vs placebo -12.0% for MTD and -6.6% for 5 mg

Early clinical trials also showed some risk, so patients with a history of acute pancreatitis were excluded from subsequent trials, and the FDA issued a warning in respect of pancreatitis risk in 2007
