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The largest of these (still fairly small, n=159) was a randomized and controlled clinical trial published in the New England Journal of Medicine , and found that a dose of 100 mcg twice per day improved quality of life, reduced eye involvement, and slowed disease progression among participants with mild Graves' orbitopathy (compared to pentoxifylline or placebo)

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Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome Evidence from a systematic review and meta-analysis

Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats

The Journal of Physiology, 591, 4655-4666

Mannitol: It has not been demonstrated to be effective in managing cerebral edema caused by hyperammonemia and therefore, it should not be given, 43 strong recommendation, low quality evidence (1C)