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Lipid overload has been suggested to cause the loss or downregulation of autophagy, leading to fat accumulation, mitochondrial disorders, inflammation, and decreased pancreatic -cell quality, all of which may eventually lead to IR and T2DM 30

Your clinician must document the relevant diagnosis and clinical history

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Additionally, GLP-1 drugs can interfere with the absorption of oral contraceptives due to slow gastric emptying, potentially reducing their effectiveness

For the study, which was published last month in the journal Diabetes, Obesity, and Metabolism , researchers at Johns Hopkins University reviewed the medical records of more than 200,000 people with type 1 diabetes from 2008 to 2023

The presence of GLP-1R in MCs has been confirmed by multiple research groups, including our own 5,15,16 and ex vivo data have shown that MCs increase their action potential firing frequency after the addition of both GLP-1 and the GLP-1R agonist exendin-4 17