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Because fixed-dose combinations contain two medicines, doubling can raise the risk of side effects

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[DOI] [PubMed] [Google Scholar] 111.Goodyer IM, Herbert J, Altham PM, Pearson J, Secher SM, Shiers HM

31 Anxiety, nervousness and insomnia were among the most frequently reported psychiatric adverse events, with a small increase in reporting frequency (ROR = 1.04)

Heartburn and gastro-oesophageal reflux disease (GORD) are reported adverse effects of this medication