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GLP-1 RAs, such as exenatide and lixisenatide, have shown benefits in addressing the pathology of PD in animal studies and phase II clinical trials, halting progression and delaying worsening of symptoms

Thus, the conjugate did not appear to interfere with the hypothalamic-pituitary-gonadal axis

Together, these data suggested that activating GLP-1R alleviated glycolysis, at least partially by the suppression of PFKFB3-driven glycolysis, and attenuated lactate-mediated histone lactylation, which in turn suppressed the transcription of profibrotic genes in TGF-1 + IL-1-challenged fibroblasts

Hammersley, D

Although much research has focused on mechanisms within the central nervous system to explain this pain suppression 8 , we hypothesize that additional mechanisms occurring in the peripheral nervous system are based on hormonal regulation during digestion