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Various studies have shown that GLP-1RAs have a kidney protective effect in patients with T2D, when considering the safety and effectiveness of GLP-1RAs in comparison to other anti-diabetic medications [100], [101], [102], [103], [104], [105]

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A contradictory result was the larger weight reduction at 3 months in people with lower initial HbA1c

While semaglutide mimics GLP-1 (glucagon-like peptide), a hormone that suppresses appetite and regulates metabolism, tirzepatide adds an analog of another gastric hormone, GIP (gastric inhibitory peptide), which increases insulin release and reduces blood sugar

Common side effects include nausea, vomiting, diarrhea, constipation, headache, dizziness, fatigue, and abdominal pain

Food and Drug Administration (FDA) to treat ulcerative colitis and are sometimes prescribed off-label (not for the approved use) to treat Crohns disease