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Glucose and insulin tolerance tests In order to assess the effects of the different pharmacotherapies on glucose tolerance, animals were subjected to an intraperitoneal glucose tolerance test (GTT) during the third week of treatment, 24 h after the last drug administration

The result is a consistent reduction in caloric intake driven not by willpower but by altered appetite signaling

Nutritional considerations for off-label use remain unclear and, given the rapidly growing public use of GLP-1s, are an important area of needed research

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