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Increased FFA in the liver results in insulin resistance, hepatic glucose production, and pancreatic beta cell dysfunction [7]

Similarly, some authors observed that metformin users had a lower clinical severity of TC at presentation and a longer disease free survival in metastatic patients (Jang et al., 2015), while other authors did not observe any difference in the risk of developing metastases when compared with non-treated patients (Noh et al., 2019)

Preclinical studies suggested that GLP-1RAs reduced immune cell activity and oxidative stress in kidney and led to decrease in fibrosis [15, 45]

T.YinW.GarousiJ.GrslundT.et al (2024)

More than 100 new cases were added in early February