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The Plateau Problem - Why GLP-1 Therapies Stop Working (and What To Do About It) Share The Plateau Problem Why GLP-1 Therapies Stop Working (and What To Do About It) GLP-1 therapies like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have delivered remarkable results for many patientsbut for a growing number, theres a common frustration: It was working and then it wasnt. Weight loss slows

The critical component in these weight-loss drugs is GLP-1 insulin, a hormone initially used to treat diabetes due to its ability to lower blood sugar levels

It works by mimicking a peptide called GLP-1 , a protein that attaches to receptors in your brain to signal fullness, stomach emptying, and insulin releases

Longer task endurance: better ability to stay with work, meetings, or school demands

Gastroparesis appears to be more common in patients with type 1 diabetes than in those with type 2 diabetes

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