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Klein JA, St-Pierre J, Choi D, Lopez J, Rubin DT

Glucagon-like peptide-1, or GLP-1, is a hormone your body naturally produces, mainly in your gut, in response to eating

The absolute reduction in LFC at week 52 was significantly greater for the tirzepatide 10 mg and 15 mg group versus the insulin degludec group

The more open TMD in the static exendin-4 bound cryo-EM structure was associated with fewer stable peptide contacts (Supplementary Table 1), relative to GLP-1 and oxyntomodulin, however, the cryo-EM map was a lower resolution, which precluded modelling of some of the binding site (top of TM6, ECL3 and ECL1)

It remains in Phase 3 clinical trials through the TRIUMPH program, which includes multiple studies examining different patient populations and endpoints