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Compared with SGLT2i alone, combination therapy was significantly associated with 42% lower risk of ischemic stroke, 37% lower risk of MI, 46% lower risk of 3-point MACE, and 45% lower risk of 5-point MACE among people with T2D and ASCVD

The results revealed that confirmed NAION cases were extremely rare, with only three cases in the treated group and five cases in the placebo group.

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