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Chen et al., 2023)

Gastrointestinal side effects, frequently observed across this drug class, pose additional challenges for adherence, particularly in populations with high vulnerability to treatment dropout

Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts

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AMPK-dependent and -independent effects of metformin on hepatic gluconeogenesis The first pharmacological activator of AMPK to be developed was 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a nucleoside that is taken up into cells and phosphorylated to the nucleotide 5-amino-4-imidazolecarboxamide riboside 5-monophosphate (ZMP), which mimics all effects of AMP on the AMPK system [28]

GLP-1 enhances meal-induced insulin secretion, the so-called incretin effect, and has several other actions that are desirable for an anti-diabetic agent [21]