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Reducing the yo-yo effect A structured approach to medication tapering that begins with medication support, and balances medical needs and costs to avoid weight regain as part of the yo-yo cycle

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doi: 10.1111/dom.15636

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GLP1 SIGNALLING IN THE PERIPHERY VERSUS CNS Classical whole animal pharmacological studies established GLP1 receptor activation promotes glucose tolerance and decreases food intake, thereby inducing weight loss and improving glucose homeostasis (Burcelin et al., 2009