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Even if the findings are validated, however, its unclear what implications they hold for the drug overdose crisis and for public health more broadly

Subgroup analyses We performed subgroup analyses of intervention population, intervention methods, and intervention duration

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It is important to recognize that clinical trials may have limited power to detect small increases in risk for specific rare cancer types, and longer-term observational studies will continue to provide important safety information

However, the evidence gap between these two agents is enormous
