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However, combining medication with modest lifestyle changes typically yields better, longer-lasting results

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More randomized data will be required to arrive at conclusive evidence.

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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1

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