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~ AlphaMD Quick Answer Gynecomastia is the noncancerous enlargement of male breast tissue that can occur when estrogen levels are elevated relative to testosterone

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Therefore, the activation of the IGF-2/IGF-1R axis may contribute to -cell survival in response to GLP-1, and importantly, the increased IGF-2 secretion may be essential for triggering this response, as also observed in embryonic development (41)

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Breast cancer screening Women with a personal or family history of hormone-sensitive cancers should discuss GLP-1 use with their oncologist