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5.2 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including RYBELSUS [see Adverse Reactions (6)]

Its recommended that women using GLP-1 medications discontinue the medication at least two months before trying to conceive

Benefits are most evident in metabolic dysfunction, where they reduce physiological stress and complement lifestyle measures without directly modifying primary aging mechanisms

Dig Dis Sci 1993

However, there was no association between GLP1RAs and reduced risk of postmenopausal breast cancer and no clear difference in breast cancer incidence among postmenopausal women treated with GLP1RAs compared to those treated with insulin or metformin [87]

These findings are summarized in Table 1, Table 2