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Placed in the context of the inflamed synovium , it is of importance that GLP-1stimulated macrophages operate an M1 to M2 switch because this results in reduced IL-6, TNF- and iNOS mRNA expression

In the patient described, her GLP-1 RA therapy may have contributed to her recurrent small bowel obstruction, particularly given her history of bowel obstruction

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Some plans may require trying a patient on a particular medication before trying the other one

What changes is the degree of receptor activation and the level of certainty surrounding expected outcomes