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GLP-1 EFFECT ON FATTY ACID OXIDATION IN LIVER AMP-activated protein kinase (AMPK) and silent mating type information regulation 2 homolog (sirtuin, SIRT) 1 are metabolic sensors regulating energy homeostasis and various intracellular systems

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AMPK, together with mTOR and its downstream target S6K1, integrate nutrient and hormonal signals to maintain energy homeostasis AMPK is a nutrient and energy sensor

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