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Drug Channels Institute coined the term gross-to-net bubble to describe the ever-inflating dollar gap between manufacturers gross and their net revenues
Cardiovascular protective properties of incretin-based therapies in type 2 diabetes

ICV GLP-1 reduces food intake in rodents, and this effect is blocked with Exendin (39)
They are released throughout the day, increasing at mealtimes, and have several functions: Stimulate the production and secretion of insulin in response to eating (glucose-dependent insulin secretion) GLP-1 enhances the sensitivity of alpha cells to glucose, resulting in more glucose-appropriate glucagon secretion Slow digestion and decrease appetite Thus, DPP-4 inhibitors indirectly enhance insulin release, suppress glucagon secretion, and improve glycaemic control

DPP4 needs dimerization for enzymatic activity, and this is the predominant form of DPP4 (15)
Interesting study