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Western blotting showed that TGF-1 + IL-1 treatment time-dependently upregulated the expression of NLRP3, ASC and active caspase-1 p20 in fibroblasts, while GSDMD-NT did not change significantly (Fig
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Increased levels of cytokines such as IL-6, IL-8, IL-1, TNF-, and IFN- as well as chemokines including chemokine receptor 2 (CCR2), C-C motif chemokine ligand 2 (CCL2), CCL5 (RANTES), and C-X-C motif chemokine ligand 10 (CXCL10) have been observed in kidney tissue of rodent models of diabetes, as well as in plasma and serum of people with DKD (43)
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Clinical Pharmacology]
