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Our functional and structural data suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy

Generic drugs account for nearly 90% of all prescriptions dispensed in the United States yet represent only about 20% of total drug spending [1]

Importantly, these effects were consistent across key subgroups (ASCVD only, CKD only, and combined), suggesting broad applicability in high-risk populations