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In a similar model, intrathecal injections of exenatide inhibited thermal hyperalgesia and mechanical allodynia by enhancing spinal microglial expression of -endorphins, IL-10 and interleukin 4 (IL-4) [34, 35]

doi: 10.1038/srep37744 (2016)

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Furthermore, exendin-4 administration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in vivo animal model of PD has been shown to inhibit microglial activation thereby minimizing the loss of dopaminergic neurons in the pars compacta of the substantia nigra and the striatum [78]