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Effects of curcumin-related compounds on GPR55 activation We compared the activation of GPR55 by curcumin with the minor curcuminoids demethoxycurcumin and bisdemethoxycurcumin, the reduced metabolite tetrahydrocurcumin, and the conjugate curcumin -d-glucuronide, which are present in vivo upon consumption of turmeric containing foods (Fig