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Consistent with our previous work (22), Dpp4 hep/ mice had significantly reduced Dpp4 mRNA expression in whole liver extracts (Supplemental Figure 2A)

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doi: 10.1046/j.1471-4159.2003.02073.x

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Monitor for reduced efficacy in the first 1-2 weeks after switching and adjust if needed

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The shock from the cold activates the parasympathetic system and can reduce stress

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NTS, nucleus of the solitary tract

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