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Employers and health plans now have multiple pathways for accessing these medications, including traditional PBM channels, direct-to-consumer programs, and emerging direct-to-employer purchasing models

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Management requires deliberate effort: fiber supplementation with psyllium husk (which is low carb), adequate water intake of at least 80 to 100 ounces daily, magnesium citrate supplementation, and regular physical activity that promotes gut motility

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[DOI] [PubMed] [Google Scholar] 228.Heisz JJ, Waddington EE

A separate 2025 systematic review and meta-analysis published in the Journal of Thrombosis and Haemostasis analyzed 27 clinical trials involving more than 84,000 patients