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Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

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The triple-agonist approachtargeting GLP-1, GIP, and glucagon receptorscreates metabolic synergy that outperforms earlier generations of GLP-1 therapy

Drucker Inhibitory effects of GLP-1 medicines on immune cell function

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8% with semaglutide after about a year)
