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Lasers in Medical Science, 32(3), 707714

The 17% average weight loss by week 24 translates to meaningful reductions in cardiac workload

10.1056/NEJMoa1706442 14

Change history 12 November 2025 The original version of this paper was updated to add the missing statements in funding

This makes it particularly harmful because it: delivers fatty acids directly to the liver worsens liver insulin resistance drives inflammation drives up sdLDL that cannot easily be removed by LDL receptors (and is principle cause of coronary artery disease) accelerates cardiovascular disease Visceral fat becomes both a marker of metabolic overload and a driver of further damage

Must be discontinued at least 2 full months before planning a pregnancy to clear the peptide