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In addition, two large-scale, double-blind, placebo-controlled phase 3 clinical studies called Evoke and Evoke + are underway to investigate the disease-mitigating potential of semaglutide in patients with AD with early symptoms and to explore its effects on AD biomarkers and neuroinflammation (Cummings et al., 2025)

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Medical Conditions Preventing Injections Certain health conditions make injections risky: Severe bleeding disorders (hemophilia, severe thrombocytopenia) Anticoagulation therapy with high bleeding risk Skin conditions affecting multiple injection sites (psoriasis, eczema, scarring) Lymphedema affecting typical injection areas Religious or Cultural Considerations Some individuals have religious or cultural objections to: Self-injection practices Specific injection methods Needle use for non-medical emergencies If these beliefs are deeply held, oral medication provides an alternative while respecting personal values

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