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doi: 10.1016/j.ceb.2011.09.003 60 BarzilaiNCrandallJPKritchevskySBEspelandMA

Frontiers in Human Neuroscience, 8

Thus, in order to have GLP/GIP analogs with lasting effects, alterations of the peptides needed to be made in order to prevent their rapid metabolism by DPP-4 and oral administration could not be used

Newer incretin-based therapies and considerations for pregnancy Emerging therapies that target multiple incretin pathways such as Retatrutide (a triple agonist targeting GLP-1, GIP and glucagon receptors) and Cagrisema (a dual agonist mimicking GLP-1 and amylin) will require thorough investigation for their safety and efficacy in pregnancy

Checked bags may be exposed to extreme temperatures, which can damage medication or make it less effective

possibly particularly for those with PCOS and/or insulin resistance
