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Phase 3 adds a 6 mg step, creating a smoother escalation that reduces the size of each dose increase

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Moreover, given that there are now millions of patient-years of clinical experience with DPP-4 inhibitors since they were given regulatory approval in 2006, their benign, placebo-like side effect profile (39) also suggests that the number of physiologically relevant substrates is likely to be limited

For someone with a history of restrictive eating, the dramatic appetite suppression could potentially trigger unhealthy patterns

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Diabetologia 2016;59:11121120 [DOI] [PMC free article] [PubMed] [Google Scholar] 42.Mann JF, Brown Frandsen K, Daniels G, et al