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This, together with the VAPB-localised cAMP FluoSTEP results from above, indicates that GLP-1R internalisation is important for GLP-1R-induced cAMP generation at VAPB loci and PKA signalling at OMMs, at least acutely

It also makes the vial harder to access cleanly when drawing doses

Translating that signal into real-world practice requires moving beyond the question of whether to combine these therapies toward the more demanding question of how, for which patients, at which stage of the transition, and with which specific formulations

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