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London, UK: Elsevier

Once ingested or injected, niacinamide is converted to nicotinamide mononucleotide (NMN) and then to NAD+ through the salvage pathway

This review examines changes in microbial composition, metabolite synthesis (such as short-chain fatty acids (SCFA), bile acids, and endotoxins), and their systemic implications by integrating clinical and preclinical data on the interactions between various drug types and the gut microbiota

The elevated cAMP levels activate PKA and Epac2, which in turn phosphorylate various target proteins, leading to alterations in gene expression, neurotransmitter release, and neuronal excitability

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