semaglutide immune system Frontiers Semaglutide and Autoimmune Disease: Safety

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2015 Jun;32(6):714-24

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Preclinical studies in rodents with long-acting GIP, GLP-1, and GLP-2 analogues, alongside related clinical trials, suggest these molecules are safe, and furthermore, may improve overall bone health

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A recent metanalysis detected that patients taking GLP-1 RA had a prolonged T 1/2 (the time required for 50% of ingested gastric contents to leave the stomach) of 138 min (confidence interval [CI] 74202 min) vs 95 min (CI 55135 min) in the placebo group, with a pooled mean difference of 36 min ( P 4 h for clear liquids with 10% carbohydrate content in patients taking GLP-1 RAs, we recommend a fasting duration of 8 h for high-calorie liquids