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Glucagon-Like Peptide 1 Receptors in Nucleus Accumbens Affect Food Intake

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On the medication side, GLP-1 receptor agonists like semaglutide and tirzepatide have a robust evidence base in their FDA-approved finished forms

Results may also depend on the dose your provider prescribes, your starting weight, and how consistently you follow a reduced-calorie diet and increased physical activity alongside the medication

What was studied: Mean change in body weight How long participants took semaglutide: 68 weeks Outcome : The semaglutide group had a mean change in body weight of -15.3 kilograms (33.73 pounds), compared to -2.6 kilograms (5.73 pounds) in the placebo group over the 68 weeks

Many insurance companies do not cover these medications, even for people who actually need them for diabetes or who could benefit from them for weight loss